AAA control AAC a_50_1 AAG a_50_10 AAT a_50_50 ACA a_50_100 ACC a_50_500 ACG a_5_100 ACT a_0.5_100 AGA a_0.05_100 AGC a_50_100_gs AGG control AGT z_50_1 ATA z_50_10 ATC z_50_50 ATG z_50_100 ATT z_50_500 CAA z_5_100 CAC z_0.5_100 CAG z_0.05_100 CAT z_50_100_gs CCA sigma CCC sigma